Medchemexpress LLC PROTAC BCR-ABL1 ligand 1 | 2489876-34-6 | 99.17% | 50 MG

Supplier:  Medchemexpress LLC HY13029750MG

PROTAC BCR-ABL1 ligand 1, also known as compound GMB-475, is a PROTAC ligand that allosterically targets the BCR-ABL1 protein. It functions by recruiting the E3 ligase Von Hippel-Lindau, which leads to the ubiquitination and subsequent degradation of BCR-ABL1.

• Allosterically targets the BCR-ABL1 protein.
• Recruits the E3 ligase Von Hippel-Lindau.
• Induces ubiquitination and subsequent degradation of BCR-ABL1.
• Inhibits cell proliferation with IC50 values of 1.11 μM for WT cells, 1.98 μM for T315I cells, and 0.37 μM for G250E cells.
• Induces the degradation of c-ABL1.
• Inhibits downstream signaling through the STAT5 pathway in K562 and Ba/F3 cells.

Catalog No. 50-003-41061