Medchemexpress LLC PROTAC BCR-ABL1 ligand 1 | 2489876-34-6 | 99.2% | 100 MG

Supplier:  Medchemexpress LLC HY130297100MG

PROTAC BCR-ABL1 ligand 1, also known as compound GMB-475, is a PROTAC ligand that allosterically targets the BCR-ABL1 protein. It recruits the E3 ligase Von Hippel-Lindau, leading to ubiquitination and subsequent degradation of BCR-ABL1. It is for research use only and not sold to patients.

• Allosterically targets the BCR-ABL1 protein.
• Recruits the E3 ligase Von Hippel-Lindau for ubiquitination and degradation of BCR-ABL1.
• Exhibits cell proliferation with IC50 values of 1.11, 1.98, and 0.37 μM for BCR-ABL1 WT, T315I, and G250E cells.
• Induces the degradation of BCR-ABL1 and c-ABL1.
• Inhibits downstream signaling via the STAT5 pathway in K562 and Ba/F3 cells.
• Intended for research use only.

Catalog No. 50-003-39880