Medchemexpress LLC PROTAC BCR-ABL1 ligand 1 | 2489876-34-6 | 99.2% | 250 MG

Supplier:  Medchemexpress LLC 250MGHY130297

PROTAC BCR-ABL1 ligand 1, also known as compound GMB-475, is a PROTAC ligand that allosterically targets the BCR-ABL1 protein. It recruits the E3 ligase Von Hippel-Lindau, leading to the ubiquitination and subsequent degradation of BCR-ABL1. It demonstrates cell proliferation inhibition with IC50 values ranging from 0.37 μM to 1.98 μM for different BCR-ABL1 cell types and induces the degradation of BCR-ABL1 and c-ABL1, inhibiting downstream signaling via the STAT5 pathway in a dose- and time-dependent manner.

• Targets the BCR-ABL1 protein allosterically
• Recruits the E3 ligase Von Hippel-Lindau
• Leads to ubiquitination and degradation of BCR-ABL1
• Induces degradation of BCR-ABL1 and c-ABL1
• Inhibits downstream signaling via the STAT5 pathway

Catalog No. 50-003-42713