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Medchemexpress LLC PROTAC CRBN Degrader-1 | 2358775-70-7 | 98.8% | 100 MG
Supplier: Medchemexpress LLC HY128845100MG
PROTAC CRBN Degrader-1 (Compound 14a) is a VHL-CRBN heterodimerization PROTAC degrader. It selectively degrades CRBN by binding two E3 ubiquitin ligases (VHL and CRBN) to each other. This compound consists of a VHL ligand, a CRBN ligand, and a linker, and is intended for research use only.
- Selectively degrades CRBN.
- Binds two E3 ubiquitin ligases (VHL and CRBN) to each other.
- Exhibits rapid degradation of CRBN (DC50=200 nM) in HeLa cells.
- Shows relatively weaker degrading activity against VHL proteins.
- Consists of a VHL ligand, a CRBN ligand, and a linker.
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