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Medchemexpress LLC PROTAC CRBN Degrader-1 | 2358775-70-7 | 98.8% | 50 MG
Supplier: Medchemexpress LLC HY12884550MG
PROTAC CRBN Degrader-1 (Compound 14a) is a VHL-CRBN heterodimerization PROTAC degrader designed to achieve selective degradation of CRBN by binding two E3 ubiquitin ligases (VHL and CRBN) to each other.
- Achieves selective degradation of CRBN
- Binds two E3 ubiquitin ligases (VHL and CRBN) to each other
- Exhibits rapid degradation of CRBN (DC50=200 nM) in HeLa cells
- Shows relatively weak degrading activity against VHL proteins
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