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Medchemexpress LLC PROTAC EGFR degrader 2 | 3031336-58-7 | 95.6% | C58H72ClFN12O8S | 1 MG
Supplier: Medchemexpress LLC HY1443041MG
PROTAC EGFR degrader 2 is a potent PROteolysis TArgeting Chimera (PROTAC) designed to degrade the Epidermal Growth Factor Receptor (EGFR). This compound demonstrates significant antiproliferative activity, with an IC50 of 4.0 nM, and effective EGFR degradation, showing a DC50 of 36.51 nM. It is also noted for its potential use in the synthesis of nitroreductase (NTR)-responsive PROTACs, indicating a mechanism that could allow for selective targeting within tumor tissues.
- Potent EGFR degradation.
- Significant antiproliferative activity.
- Leverages the cell's ubiquitin-proteasome system to induce EGFR degradation.
- Can be used in the development of nitroreductase (NTR)-responsive PROTACs for targeted therapies.
- Demonstrates antiproliferative activity against various human cell lines.
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