Medchemexpress LLC PROTAC EGFR degrader 4 | 2882845-50-1 | 99.7% | 995.29 | 1 MG

Supplier:  Medchemexpress LLC HY1463491MG

PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR. It induces degradation of EGFRdel19 and EGFRL858R/T790M with DC50s of 0.51 and 126 nM, respectively. The compound significantly inhibits the growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. The induced EGFR degradation is associated with autophagy.

• Displays excellent activity of inducing EGFRdel19 degradation with a DC50 value of 0.51 nM.
• Dramatically reduces the phosphorylation of EGFR and its downstream effector Akt in HCC827 and H1975 cell lines.
• Induces HCC827 cell line to undergo apoptosis at concentrations of 10 and 100 nM.
• Arrests both HCC827 and H1975 cell lines at G1 phase.

Catalog No. 50-003-63516