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Medchemexpress LLC PROTAC EGFR degrader 4 | 2882845-50-1 | 99.7% | 995.29 | 25 MG
SDP

Catalog No. 5000362729
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PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant Epidermal Growth Factor Receptor (EGFR). It induces degradation of EGFRdel19 and EGFRL858R/T790M mutations. This compound inhibits the growth of cancer cell lines (e.g., HCC827, H1975), with its EGFR degradation linked to autophagy.

  • Potent degrader of mutant EGFR.
  • Induces degradation of specific EGFR mutations (EGFRdel19 and EGFRL858R/T790M).
  • Inhibits growth of specific cancer cell lines.
  • Its degradation mechanism is related to autophagy.
  • Displays antiproliferative activity against various cancer cells, including those expressing wild-type EGFR.
  • Reduces phosphorylation of EGFR and its downstream effector Akt.
  • Induces apoptosis and G1 phase arrest in cancer cell lines.

Catalog No. 50-003-62729 Supplier Medchemexpress LLC Supplier No. 25MGHY146349
May include imposed supplier surcharges.
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PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant Epidermal Growth Factor Receptor (EGFR). It induces degradation of EGFRdel19 and EGFRL858R/T790M mutations. This compound inhibits the growth of cancer cell lines (e.g., HCC827, H1975), with its EGFR degradation linked to autophagy.

  • Potent degrader of mutant EGFR.
  • Induces degradation of specific EGFR mutations (EGFRdel19 and EGFRL858R/T790M).
  • Inhibits growth of specific cancer cell lines.
  • Its degradation mechanism is related to autophagy.
  • Displays antiproliferative activity against various cancer cells, including those expressing wild-type EGFR.
  • Reduces phosphorylation of EGFR and its downstream effector Akt.
  • Induces apoptosis and G1 phase arrest in cancer cell lines.

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