Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000394572

Medchemexpress LLC PROTAC EGFR degrader 9 | 2992670-33-2 | 98.4% | 899.98 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1615365MG

Encompass_Preferred

PROTAC EGFR degrader 9 (Compound C6) is an orally active CRBN-based PROTAC EGFR degrader. It demonstrates a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. This degrader exhibits potent degradation activity against various EGFR mutants while sparing EGFRWT. The compound is for research use only and not sold to patients.

  • Orally active CRBN-based PROTAC EGFR degrader.
  • Exhibits potent degradation activity against various EGFR mutants (EGFRL858R/T790M/C797S, EGFRdel19 T790M C797S, EGFRL858R/T790M, EGFRdel19).
  • Spares EGFRWT.
  • Inhibits NSCLC tumor growth in vivo without obvious toxicity.
  • Reduces EGFR protein level and inhibits EGFR phosphorylation in tumor tissues.
  • Arrests H1975-TM cells in the G0/G1 phase.
  • Promotes cell apoptosis in H1975-TM cells.

Catalog No. 50-003-94572


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.