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Medchemexpress LLC PROTAC EZH2 Degrader-1 | 2641601-67-2 | 99.4% | 942.15 | 25 MG
Supplier: Medchemexpress LLC 25MGHY147525
PROTAC EZH2 Degrader-1 (Compound 150d) is a potent PROTAC EZH2 Degrader that inhibits EZH2 methyltransferase activity with an IC50 of 2.7 nM. EZH2 is critical in many tumorigenesis and development processes.
- Potently inhibits EZH2 methyltransferase activity (IC50: 2.7 nM).
- Demonstrates anti-proliferative activity against human EOL1, MV4-11, Pfeiffer, RS4-11, and WSUDLCL2 cells.
- Inhibits cell viability in H128-LM, H128-BPM, H128 wildtype, and H128-Mut cells.
- Enhances sensitivity of H128-LM cells to Carboplatin, VP16, and VM26.
- Exhibits antitumor activity in H128-LM xenograft mouse models, prolonging survival when combined with Carboplatin, VP16, or VM26.
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