Medchemexpress LLC Protac EZH2 Degrader-1 | 2641601-67-2 | 99.4% | 942.15 | 50 MG

Supplier:  Medchemexpress LLC HY14752550MG

PROTAC EZH2 Degrader-1 (Compound 150d) is a potent PROTAC EZH2 Degrader that inhibits EZH2 methyltransferase activity with an IC50 of 2.7 nM. EZH2 is critical in many tumorigenesis and development processes.

• Potent PROTAC EZH2 Degrader with an IC50 of 2.7 nM for EZH2 methyltransferase activity.
• Exhibits anti-proliferative activity against various cell lines such as EOL1 (IC50: 3.7 μM), MV4-11 (IC50: 5.5 μM), Pfeiffer (IC50: 0.21 μM), RS4-11 (IC50: 5 μM), and WSUDLCL2 (IC50: 3.69 μM).
• Inhibits cell viability in H128-LM (IC50: 1.83 nM), H128-BPM (IC50: 1.9 nM), H128 wildtype (IC50: 3.07 nM), and H128-Mut (IC50: 2.64 nM) cells.
• Enhances the sensitivity of H128-LM cells to Carboplatin, VP16, and VM26.
• Demonstrates antitumor activity against H128-LM in xenograft mouse models when combined with Carboplatin, VP16, or VM26, prolonging survival.

Catalog No. 50-003-60988