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Medchemexpress LLC Protac IDO1 degrader-1 | 2488851-89-2 | 99.0% | 966.80 g·mol⁻¹ | C40H53BrFN9O13 | 5 MG
Supplier: Medchemexpress LLC HY1319115MG
PROTAC IDO1 Degrader-1 is a research-grade proteolysis targeting chimera (PROTAC) that selectively induces degradation of indoleamine 2,3-dioxygenase 1 (IDO1) by recruiting cereblon E3 ligase, leading to ubiquitination and proteasomal degradation. Cellular studies demonstrate dose-dependent IDO1 degradation and functional enhancement of tumor-killing activity in CAR-T assays.
- Induces selective IDO1 degradation in cells (DC50 = 2.84 μM).
- Displays IDO1 inhibitory potency (IC50 = 1.07 μM).
- Produces up to 93% maximum degradation in HeLa cells.
- Soluble in DMSO at 100 mg/mL; in vivo co-solvent formulations reported with ≥2.5 mg/mL solubility.
- Store sealed at -20°C; in solution: -80°C up to 6 months, -20°C up to 1 month.
- For research use in cellular and in vivo studies.
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