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LifeSensors PROTAC In Vitro Ubiquitination Assay Kit
Supplier: LifeSensors PA0770P100R
Proteolysis Targeting Chimeras (PROTACs) have emerged as novel therapeutics to target the undruggable proteome. PROTACs are heterobifunctional small molecules that both simultaneously bind to a target protein and a ubiquitin (Ub) E3 ligase. This subsequently leads to ubiquitination and degradation of the target protein. The In vitro ubiquitination kit has been developed to establish a high throughput approach that can accurately predict PROTAC efficiency by monitoring the protein’s intrinsic ability to get ubiquitinated. We offer this kit for three E3 ubiquitin ligases: Cereblon, VHL, and HDM2 to monitor PROTAC mediated ubiquitination for target of choice.For evaluating molecular glues, we recommend using our MG780: Molecular Glue In Vitro Ubiquitination Assay Kit. This kit is specially designed to measure the performance of molecular glues In vitro.
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