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Medchemexpress LLC PROTAC KRAS G12D degrader 1 | 3033583-54-6 | 98.3% | 1103.33 | 50 MG
SDP

Catalog No. 5000393087
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PROTAC KRAS G12D degrader 1 is a selective PROTAC KRASG12D degrader that inhibits proliferation of KRASG12D-mutant cells and suppresses ERK phosphorylation. It inhibits tumor growth in mice bearing AsPC-1 xenografts and can be used for the study of KRASG12D-driven cancers.

  • Selective PROTAC KRASG12D degrader.
  • Inhibits proliferation of KRASG12D-mutant cells.
  • Suppresses ERK phosphorylation.
  • Inhibits tumor growth in mice bearing AsPC-1 xenografts.
  • Can be used for the study of KRASG12D-driven cancers.
  • Dose-dependently degrades KRASG12D in SNU-1, HPAF-II, AGS, and PANC 04.03 cells.
  • Significantly decreases KRASG12D protein level in AsPC-1 cells.
  • Leads to sustained KRASG12D degradation and pERK inhibition in AsPC-1 cells.
  • Reduced KRASG12D protein level and phosphorylation level of ERK in AsPC-1 xenograft tumor tissues.
  • Downregulated the mRNA level of DUSP4.

Catalog No. 50-003-93087 Supplier Medchemexpress LLC Supplier No. HY16117650MG
May include imposed supplier surcharges.
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PROTAC KRAS G12D degrader 1 is a selective PROTAC KRASG12D degrader that inhibits proliferation of KRASG12D-mutant cells and suppresses ERK phosphorylation. It inhibits tumor growth in mice bearing AsPC-1 xenografts and can be used for the study of KRASG12D-driven cancers.

  • Selective PROTAC KRASG12D degrader.
  • Inhibits proliferation of KRASG12D-mutant cells.
  • Suppresses ERK phosphorylation.
  • Inhibits tumor growth in mice bearing AsPC-1 xenografts.
  • Can be used for the study of KRASG12D-driven cancers.
  • Dose-dependently degrades KRASG12D in SNU-1, HPAF-II, AGS, and PANC 04.03 cells.
  • Significantly decreases KRASG12D protein level in AsPC-1 cells.
  • Leads to sustained KRASG12D degradation and pERK inhibition in AsPC-1 cells.
  • Reduced KRASG12D protein level and phosphorylation level of ERK in AsPC-1 xenograft tumor tissues.
  • Downregulated the mRNA level of DUSP4.

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