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Medchemexpress LLC Protac-o4i2 | 2785323-62-6 | 99.6% | C29H29ClN6O5S | 100 MG
SDP

Supplier:  Medchemexpress LLC HY141881100MG

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PROTAC-O4I2 is a PROTAC (proteolysis-targeting chimera) that targets splicing factor 3B1 (SF3B1). It induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells and cellular apoptosis in K562 WT cells. It introduces Thalidomide to ubiquitin E3 ligase cereblon (CRBN) which selectively degrades SF3B1 and inhibits tumor growth in cells.

  • Degrades and inhibits SF3B1 in K562 cells.
  • Exhibits anti-proliferation effects on SF3B1 WT, SF3B1 OE, and SF3B1 K700E cells.
  • Induces FLAG-SF3B1 degradation.
  • Increases survival by interfering with tumor maintenance and proliferation in a Drosophila intestinal tumor model.

Catalog No. 50-003-54833


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