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Medchemexpress LLC PROTAC STING Degrader-1 | 2762552-74-7 | C34H33N7O10 | 5 MG
Supplier: Medchemexpress LLC HY1506085MG
PROTAC STING Degrader-1 is a PROTAC degrader targeting the STING pathway, demonstrating high anti-inflammatory efficacy with a DC50 of 3.2 μM. It is valuable for studying diseases such as acute kidney injury and inflammatory bowel diseases.
- Targets the STING pathway with a DC50 of 3.2 μM.
- Exhibits high anti-inflammatory efficacy.
- Useful for studying acute kidney injury and inflammatory bowel diseases.
- Downregulates STING pathway signals (IFN-β, IL-6, CXCL10) in THP-1 cells.
- Degrades STING dose- and time-dependently.
- Demonstrates no significant cytotoxicity below 10 μM.
- Alleviates ischemic symptoms and reduces kidney weights in acute kidney injury mouse models.
- Ameliorates severity of DSS-induced colitis in mice.
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