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Medchemexpress LLC PROTAC STING degrader-3 | 98.04% | 752.73 | 5 MG
Supplier: Medchemexpress LLC HY1734145MG
PROTAC STING degrader-3 is a STING PROTAC degrader that induces STING degradation via the ubiquitin-proteasome pathway. It exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling and has renal protective effects, being used in the study of acute kidney injury (AKI).
- Sting PROTAC degrader (DC50: 0.62 μM)
- Induces STING degradation via ubiquitin-proteasome pathway
- Exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling
- Renal protective effects for acute kidney injury (AKI) studies
- Potently degrades STING protein in THP-1 cells
- Blocks STING/NF-κB downstream signaling axis in HK-2 cells
- Demonstrates selective degradation of STING protein
- Favorable in vitro safety profile
- Improves renal function and survival in AKI mice
- Suppresses expression of STING proteins and inflammatory factors
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