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Apexbio Technology LLC PRT062607 Hydrochloride 1370261-97-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A37365.1
PRT062607 Hydrochloride (CAS 1370261-97-4) is a selective inhibitor of spleen tyrosine kinase (SYK) a cytoplasmic kinase involved predominantly in hematopoietic signaling pathways notably within B cells It demonstrates potent inhibitory activity with an IC50 of approximately 1 nM and shows high selectivity for SYK over a range of other kinases Treatment of non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) B cell lines with PRT062607 Hydrochloride results in inhibition of SYK activation and induction of caspase-dependent apoptosis In murine xenograft models employing Ramos tumor cells systemic administration reduces tumor growth These features highlight PRT062607 Hydrochloride as a tool compound valuable for studying B cell malignancies and SYK-mediated signaling events
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