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Medchemexpress LLC PRX-08066 | 866206-54-4 | C19H17ClFN5S | 1 MG
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Supplier:  Medchemexpress LLC HY154721MG

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PRX-08066 is a selective and orally active 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist. It inhibits the MAPK pathway, 5-HT release, and the expression of fibrotic factors. This product can be used for research related to pulmonary Arterial Hypertension (PAH) and neuroendocrine tumors (NET).

  • Selective and orally active 5-HT2BR antagonist (Ki of 3.4 nM)
  • Inhibits MAPK pathway and 5-HT release
  • Inhibits expression of fibrotic factors (TGFβ1, CTGF, and FGF2)
  • Inhibits proliferation of KRJ-I cells
  • Induces apoptosis via caspase-3 activation
  • Inhibits pulmonary vascular remodeling

Catalog No. 50-003-76588


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