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Medchemexpress LLC PS-1145 | 431898-65-6 | 99.67% | 322.75 | 25 MG
Supplier: Medchemexpress LLC 25MGHY18008
PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
- Blocks TNFα-induced NF-κB activation in a dose- and time-dependent manner in MM cells through inhibition of IκBα phosphorylation.
- Dexamethasone enhances the blockade of NF-κB activation by the product.
- Blocks the protective effect of IL-6 against Dexamethasone-induced apoptosis.
- Inhibits TNFα-induced intracellular adhesion molecule (ICAM)-1 expression.
- Inhibits both IL-6 secretion from bone marrow stromal cells (BMSCs) triggered by MM cell adhesion and proliferation of MM cells adherent to BMSCs.
- Administration results in a significant decrease in serum levels of three cytokines.
- Blocks hypothalamic inflammation induced by IL-4.
- Decreases IL-1β mRNA content.
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