Medchemexpress LLC PS-1145 | 431898-65-6 | 99.7% | 322.75 | 50 MG

Supplier:  Medchemexpress LLC HY1800850MG

PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM. It blocks TNFα-induced NF-κB activation in MM cells by inhibiting IκBα phosphorylation. Dexamethasone enhances the blockade of NF-κB activation by PS-1145.

• Blocks TNFα-induced NF-κB activation.
• Inhibits IκBα phosphorylation.
• Enhances blockade of NF-κB activation by Dexamethasone.
• Blocks protective effect of IL-6 against Dex-induced apoptosis.
• Inhibits TNFα-induced intracellular adhesion molecule (ICAM)-1 expression.
• Inhibits IL-6 secretion from bone marrow stromal cells.
• Inhibits proliferation of MM cells adherent to bone marrow stromal cells.

Catalog No. 50-003-87486