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Medchemexpress LLC PSB 0777 ammonium hydrate | 99.68% | 532.09 | 1 MG
SDP

Catalog No. 5000352229
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PSB 0777 ammonium hydrate is a potent and selective full agonist for the adenosine A2A receptor, showing high affinity for rat and human A2A receptors. It demonstrates significantly lower affinity for rat and human A1 receptors, highlighting its selectivity. With poor brain penetration and oral non-absorbability, it suggests localized effects and potential for inflammatory bowel disease (IBS) research.

  • High selectivity for A2AAR (>225-fold) over other adenosine receptor subtypes.
  • Functions as a full agonist at A2AAR with an EC50 value of 117 nM in CHO-K1 cells.
  • In vivo, oral gavage reduces inflammatory cell infiltration and improves colonic mucosal architecture in a rat colitis model.
  • Poor systemic absorption after oral administration, suggesting localized effects.

Catalog No. 50-003-52229 Supplier Medchemexpress LLC Supplier No. HY136233A1MG
May include imposed supplier surcharges.
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PSB 0777 ammonium hydrate is a potent and selective full agonist for the adenosine A2A receptor, showing high affinity for rat and human A2A receptors. It demonstrates significantly lower affinity for rat and human A1 receptors, highlighting its selectivity. With poor brain penetration and oral non-absorbability, it suggests localized effects and potential for inflammatory bowel disease (IBS) research.

  • High selectivity for A2AAR (>225-fold) over other adenosine receptor subtypes.
  • Functions as a full agonist at A2AAR with an EC50 value of 117 nM in CHO-K1 cells.
  • In vivo, oral gavage reduces inflammatory cell infiltration and improves colonic mucosal architecture in a rat colitis model.
  • Poor systemic absorption after oral administration, suggesting localized effects.

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