P-selectin (SELP), also known as CD62P, is a cell adhesion molecule (CAM) expressed on the surfaces of activated endothelial cells and platelets. It plays a critical role in leukocyte recruitment and has been implicated in tumor metastasis. This human P-selectin protein is expressed in human HEK293 cells and contains a C-terminal polyhistidine tag.
- Greater than 95% purity as determined by SDS-PAGE.
- Calculated molecular weight of 81.8 kDa, migrating at 110–125 kDa under reducing conditions due to glycosylation.
- Endotoxin level is less than 1.0 EU per μg by the LAL or rFC method.
- Lyophilized from a 0.22 μm filtered PBS solution, pH 7.4, with trehalose as a protectant.
- Stable for 12 months at -20°C to -70°C in lyophilized state and 3 months at -70°C after reconstitution under sterile conditions.