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Cayman Chemical PseudogInsenosIde F11 25mg

Supplier: Cayman Chemical 3022225 MG

An irreversible inhibitor of the NLRP3 inflammasome inhibits activation of caspase-1 and release of IL-1B and LDH induced by ATP or nigericin in LPS-primed BMDMs at 10 UM reduces ATP-induced pyroptosis in LPS-primed THP-1 cells by 33 6 at 10 UM prevents increases in IL-1B protein levels induced by DNBS in the colon in a rat model of colitis reduces the severity of pancreatic lesions and serum levels of IL-1B TNF-a and IL-6 during caerulein- and LPS-induced pancreatitis in mice at 25 and 50 mg/kg
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