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Medchemexpress LLC Pseudoprotodioscin | 102115-79-7 | 1031.18 | 20 MG
Supplier: Medchemexpress LLC HYN068620MG
Pseudoprotodioscin is a furostanoside that inhibits SREBP1/2 and microRNA 33a/b levels, leading to a reduction in gene expression related to the synthesis of cholesterol and triglycerides. In Hep G2 cells, it increases ABCA1 protein and mRNA levels and promotes the efflux of ApoA-1-mediated cholesterol. It also inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels, which reciprocally increases ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin reduces HMGCR, FAS, and ACC mRNA levels and promotes low-density lipoprotein receptor by decreasing PCSK9 levels.
- Inhibits SREBP1/2 and microRNA 33a/b levels.
- Reduces gene expression concerning cholesterol and triglyceride synthesis.
- Increases ABCA1 protein and mRNA levels.
- Promotes ApoA-1-mediated cholesterol efflux.
- Reduces HMGCR, FAS, and ACC mRNA levels.
- Promotes low-density lipoprotein receptor by decreasing PCSK9 levels.
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