AdipoGen PSGL-1 (human):Fc (human) (rec.) (50 µg)

Supplier:  AdipoGen AG40B0190C050

Protein. The extracellular domain of human PSGL-1 (aa 42-305) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test). Lyophilized. Contains PBS. Purity: >95% (SDS-PAGE). In addition to its migratory properties, the adhesion protein PSGL-1 also functions in a selectin-independent manner as a negative regulator of T cell responses in contexts of chronic viral infection, cancer and some autoimmune diseases. PSGL-1 expressed on leukocytes binds to multimeric VISTA at acidic pH, but not at the physiological pH 7. VISTA - PSGL-1 interaction shows that immune response can be regulated by acidic environments found in tumors. Identification of PSGL-1 - VISTA signaling pathways in T cells could lead to new therapeutic targets that increase immune function, such as in chronic viral infections or in cancer, or attenuate immune function such as in autoimmunity.

Catalog No. 50-205-3290