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ABclonal Technology PSMC1 Rabbit pAb
Supplier: ABclonal Technology A157121000UL
The 26S proteasome is a multicatalytic proteinase complex consisting of a 20S core and a 19S regulator. The 20S core has 4 rings of 28 subunits, while the 19S regulator contains ATPase and non-ATPase subunits. Proteasomes cleave peptides in an ATP/ubiquitin-dependent process, important for class I MHC peptide processing. This gene encodes an ATPase subunit of the triple-A ATPase family with chaperone-like activity. It interacts with the hepatitis B virus X protein, critical for viral replication, and the adenovirus E1A protein, modifying proteasome activity. The subunit also interacts with ataxin-7, indicating a role in spinocerebellar ataxia type 7, a neurodegenerative disorder.
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