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ABclonal Technology PSMC5 Rabbit mAb
Supplier: ABclonal Technology A20969100UL
The 26S proteasome is a multicatalytic complex composed of a 20S core and a 19S regulator The 20S core has four rings of 28 subunits (two rings of 7 alpha and two of 7 beta subunits) The 19S regulator includes a base (6 ATPase and 2 non-ATPase subunits) and a lid (up to 10 non-ATPase subunits) Proteasomes abundant in eukaryotic cells degrade peptides in an ATP- and ubiquitin-dependent manner outside of lysosomes The immunoproteasome variant processes MHC class I peptides This gene encodes one of the ATPase subunits part of the AAA family of ATPases with chaperone-like activity Beyond proteasome function this subunit may regulate transcription by interacting with thyroid hormone and retinoid X receptors Two transcript variants encoding different isoforms exist
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