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Apexbio Technology LLC PTC209 HBr 1217022-63-3 10mM (in 1mL DMSO)
SDP

Catalog No. 5000088896
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PTC209 HBr (CAS 1217022-63-3) is the hydrobromide salt form of PTC-209 known as a selective inhibitor of BMI-1 a component of the Polycomb Repressive Complex 1 (PRC1) involved in epigenetic regulation PTC209 HBr inhibits BMI-1 with an IC50 of 0 5 M and suppresses both UTR-mediated reporter activity and endogenous BMI-1 expression in HCT116 colorectal and HT1080 fibrosarcoma cells in a dose-dependent manner independent of cytotoxic effects In vivo treatment of colorectal cancer cells with PTC209 HBr prior to xenotransplantation into mice results in reduced or arrested tumor growth This compound is utilized in studies of cancer stem cell biology and epigenetic modulation in colorectal cancer

Catalog No. 50-000-88896 Supplier Apexbio Technology LLC Supplier No. B49715.1
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PTC209 HBr (CAS 1217022-63-3) is the hydrobromide salt form of PTC-209 known as a selective inhibitor of BMI-1 a component of the Polycomb Repressive Complex 1 (PRC1) involved in epigenetic regulation PTC209 HBr inhibits BMI-1 with an IC50 of 0 5 M and suppresses both UTR-mediated reporter activity and endogenous BMI-1 expression in HCT116 colorectal and HT1080 fibrosarcoma cells in a dose-dependent manner independent of cytotoxic effects In vivo treatment of colorectal cancer cells with PTC209 HBr prior to xenotransplantation into mice results in reduced or arrested tumor growth This compound is utilized in studies of cancer stem cell biology and epigenetic modulation in colorectal cancer

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