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Cayman Chemical PTENCTerm RabbIt Monclon 100uL
SDP

Catalog No. 502947820
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A selective estrogen receptor covalent antagonist covalently modifies cysteine 530 in the ligand binding domain of wild-type ERa and ERaY537S inhibits expression of the ERa target genes GREB1 and TFF1 in MCF-7 cells overexpressing wild-type ERa (IC50s 2.74 and 1.3 nM respectively) ERaY537S (IC50s 29.38 and 19.4 nM respectively) ERaY537N (IC50s 8.14 and 6.1 nM respectively) ERaY537C (IC50s 12.19 and 9.5 nM respectively) or ERaD538G (IC50s 24.87 and 4 nM respectively) inhibits the growth of MCF-7 cells overexpressing wild-type ERa or ERaY537S (GI50s 1.3 and 8.3 nM respectively) reduces tumor growth in an MCF-7 mouse xenograft model and an ERaY537S/WT ST941 PDX mouse model in a dose-dependent manner

Catalog No. 50-294-7820 Supplier Cayman Chemical Supplier No. 32215100 UL
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A selective estrogen receptor covalent antagonist covalently modifies cysteine 530 in the ligand binding domain of wild-type ERa and ERaY537S inhibits expression of the ERa target genes GREB1 and TFF1 in MCF-7 cells overexpressing wild-type ERa (IC50s 2.74 and 1.3 nM respectively) ERaY537S (IC50s 29.38 and 19.4 nM respectively) ERaY537N (IC50s 8.14 and 6.1 nM respectively) ERaY537C (IC50s 12.19 and 9.5 nM respectively) or ERaD538G (IC50s 24.87 and 4 nM respectively) inhibits the growth of MCF-7 cells overexpressing wild-type ERa or ERaY537S (GI50s 1.3 and 8.3 nM respectively) reduces tumor growth in an MCF-7 mouse xenograft model and an ERaY537S/WT ST941 PDX mouse model in a dose-dependent manner

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