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BioVendor, LLC Parathyroid Hormone (PTH) Human ELISA (96 wells)
Supplier: BioVendor, LLC RIS003R
Parathyroid Hormone (PTH) Human ELISA, 96 wells. RUO immunoassay kit to quantify human Intact PTH in serum or plasma. QCs included. Calib. range 151040 pg/ml. Detection limit 2 pg/ml. Synonym: Parathormone, Parathyrin. Summary: hPTH increases serum calcium concentrations by its actions on kidney and bone. It indirectly affects intestinal absorption of Ca++ by stimulating renal 1-hydroxylation of 25(OH)D3. PTH release is controlled in a negative feedback loop by serum concentration of Ca++. Intact PTH is the main bioactive product and is proteolytically degraded to form biologically active N-terminal fragments and inactive C-terminal fragments. C-terminal fragments are cleared only by glomerular filtration, while the bioactive intact PTH and N-terminal fragments are also degraded in the liver and other tissues. C-terminal fragment half-life increases dramatically in patients with renal failure. Thus, intact PTH level correlates best with the hormone production and biological activity.
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