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Enzo Life Sciences PTP1B drug discovery kit (1x96wells)
Supplier: Enzo Life Sciences BMLAK8220001
The PTP1B Tyrosine Phosphatase Drug Discovery Kit is a colorimetric, non-radioactive assay designed to measure the phosphatase activity of purified PTP1B. This 96-well assay is useful for screening inhibitors and modulators of PTP1B activity.The kit includes human, recombinant PTP1B (residues 1-322; MW=37.4 kDa), expressed in E. coli. The detection of free phosphate released is based on the classic Malachite green assay and offers the advantages of convenient, 1-step detection and excellent sensitivity, without radioactivity. PTP1B (protein tyrosine phosphatase-1B) is a ubiquitous, nontransmembrane protein tyrosine phosphatase, originally identified in human placenta. It is implicated in the negative regulation of insulin receptor signaling, and is a potential therapeutic target for treatment of type 2 diabetes and obesity. Applications: Colorimetric detection, HTS .
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