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Medchemexpress LLC Pulrodemstat (benzenesulfonate) | 2097523-60-7 | 99.6% | 1 ML
SDP

Supplier:  Medchemexpress LLC HY129388B10MM/1ML

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Pulrodemstat benzenesulfonate is a potent, selective, reversible, and orally active inhibitor of lysine specific demethylase-1 (LSD1), with an IC50 of 0.25 nM. It demonstrates less enzymatic inhibition against LSD2, MAO-A, and MAO-B. This compound induces differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells, exhibiting potent anticancer activity.

  • Potent, selective, reversible, and orally active LSD1 inhibitor (IC50 0.25 nM)
  • Induces differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells
  • Exhibits potent anticancer activity
  • Shows antiproliferative activity in AML kasumi-1 cells (EC50 2 nM)
  • Inhibits tumor growth in patient-derived xenograft SCLC models
  • Downregulates GRP mRNA levels

Catalog No. 50-003-41348


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