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Medchemexpress LLC Purinostat mesylate | 2650188-32-0 | 99.5% | 586.62 | 25 MG
Supplier: Medchemexpress LLC 25MGHY150109
Purinostat mesylate is a selective inhibitor of HDAC. It inhibits class I and class IIb HDACs with IC50s ranging from 0.81 to 11.5 nM. It induces apoptosis and affects the cell cycle of LAMA84 and 188 BL-2 cells, showing potent anti-leukemia effects in vivo. It is used for research on lymphoblastic leukemia.
- Inhibits class I and class IIb HDACs
- Induces apoptosis and affects cell cycle of LAMA84 and 188 BL-2 cells
- Suppresses leukemia progression in vivo
- Demonstrates potent anti-leukemia effects in BCR-ABL(T315I)-induced primary B-ALL mice
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