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Medchemexpress LLC Purmorphamine | 483367-10-8 | C31H32N6O2 | 250 MG
Supplier: Medchemexpress LLC 250MGHY15108
Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM. This compound, appearing as a white to off-white solid, has a molecular weight of 520.62 and a chemical formula of C31H32N6O2. It induces up-regulation of alkaline phosphatase activity, RUNX-2, and osteocalcin, and also induces STAT3 phosphorylation in mouse ES cell line ES14 and mesenchymal stem cell line C3H10T1/2.
- Acts as a smoothened/Smo receptor agonist
- Induces up-regulation of alkaline phosphatase activity and RUNX-2 expression
- Promotes up-regulation of osteocalcin
- Induces STAT3 phosphorylation in mouse ES cell line ES14 and mesenchymal stem cell line C3H10T1/2
- Decreases cell numbers when combined with sirolimus
- Up-regulates markers of the osteoblast phenotype in human bone marrow mesenchymal cells
- Cited in studies for various assays including CCK-8, cell counting, and in vivo efficacy
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