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AdipoGen Puromycin . dihydrochloride Chemical. CAS: 58-58-2
Supplier: AdipoGen AGCN20078M100
Puromycin . dihydrochloride , AdipoGen Life Sciences. Chemical. CAS: 58-58-2. Formula: C22H29N7O5 . 2HCl. MW: 471.5 . 72.9. Isolated from Streptomyces alboniger. Aminonucleoside antibiotic. Protein synthesis inhibitor. Disrupts peptide transfer on ribosomes (acting as an acyl-tRNA analog) causing premature chain termination during translation. Translational inhibitor in prokaryotic and eukaryotic cells in both in vitro and in vivo systems. Inhibits the transport of proteins into the mitochondria in vitro. Reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase (metallopeptidase). Apoptosis inducer. Inhibits the growth of Gram-positive bacteria, various animal and insect cells. Fungi and Gram-negative bacteria are resistant due to the low permeability to the antibiotic. Antineoplastic agent. Used in cell biology as selective agent in cell culture systems.
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