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Apexbio Technology LLC PUROMYCIN AMINONUCLEOSID 250MG

Supplier: Apexbio Technology LLC A3740250

Puromycin aminonucleoside (CAS 58-60-6) is the aminonucleoside moiety derived from the antibiotic puromycin It induces nephrotic injury in experimental animal models leading to significant proteinuria and structural alterations in renal glomeruli In vitro treatment with puromycin aminonucleoside alters podocyte morphology characterized by reductions in cellular microvilli and disruption of foot-process structures In vivo administration in rats induces glomerular lesions resembling focal segmental glomerulosclerosis (FSGS) and lipid accumulation in mesangial cells This compound serves primarily as an investigative tool in elucidating mechanisms underlying nephrotic syndrome
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