Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Apexbio Technology LLC Puromycin dihydrochloride, 50mg CAS# 58-58-2
SDP

Supplier:  Apexbio Technology LLC B758750

Encompass_Preferred

Puromycin dihydrochloride [1] is an analog of aminoacyl-tRNA. Puromycin dihydrochloride allows selection for cells expressing the resistance gene puromycin N-acetyl-transferase (PAC) and is useful in CRISPR/Cas9 mammalian gene editing by selecting for successful Cas9-induced knock-in with puromycin resistance gene. It inhibits the incorporation of aminoacyl-tRNA into the C-terminal on a synthesizing polypeptide, resulting in the premature termination of the polypeptide chain.Puromycin is toxic to the growth of various eukaryote cells including mammalian cells. Concentrations of puromycin sufficient to inhibit the cell growth of mammalian cells range from 0.5-10 g/ml. IC90s for puromycin to inhibit the growth of Plasmodium falciparum and Giardia lamblia are 60 ng/ml and 54 g/ml, respectively [2]. Aminoacyl-tRNA is used as the material for elongation of a synthesizing polypeptide on a ribosome. Other sizes are also available. Please inqury us for quote.

Catalog No. 50-199-8342


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.