Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000088617

Apexbio Technology LLC Purvalanol A 212844-53-6 10mM (in 1mL DMSO)
SDP

Catalog No. 5000088617
Encompass_Preferred

Purvalanol A (CAS 212844-53-6) is a potent and selective inhibitor of cyclin-dependent kinases (CDKs) exhibiting IC50 values of 4 nM for cdc2-cyclin B 35 nM for CDK2-cyclin E 70 nM for CDK2-cyclin A 75 nM for CDK5-p35 and 850 nM for CDK4-cyclin D1 By targeting CDKs Purvalanol A disrupts cell cycle regulation transcription and neuronal differentiation processes In cellular studies it decreases levels of anti-apoptotic proteins and induces apoptosis partly through inhibition of JAK2/STAT3 signaling and RNA polymerase II phosphorylation Additionally Purvalanol A modulates polyamine catabolic pathways and affects cell proliferation in neural tissues supporting its utility in cell cycle apoptosis and neurobiology research

Catalog No. 50-000-88617 Supplier Apexbio Technology LLC Supplier No. B49905.1
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

Purvalanol A (CAS 212844-53-6) is a potent and selective inhibitor of cyclin-dependent kinases (CDKs) exhibiting IC50 values of 4 nM for cdc2-cyclin B 35 nM for CDK2-cyclin E 70 nM for CDK2-cyclin A 75 nM for CDK5-p35 and 850 nM for CDK4-cyclin D1 By targeting CDKs Purvalanol A disrupts cell cycle regulation transcription and neuronal differentiation processes In cellular studies it decreases levels of anti-apoptotic proteins and induces apoptosis partly through inhibition of JAK2/STAT3 signaling and RNA polymerase II phosphorylation Additionally Purvalanol A modulates polyamine catabolic pathways and affects cell proliferation in neural tissues supporting its utility in cell cycle apoptosis and neurobiology research

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.