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Medchemexpress LLC PVD-06 | 3032975-48-4 | 98.3% | 1074.13 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1497601MG

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PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM. It induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-γ-mediated anticancer activity, making it suitable for investigating PTPN2 in diseases such as leukemia and melanoma.

  • Selective PROTAC PTPN2 degrader
  • Induces PTPN2 degradation via VHL-, ubiquitin, and proteasome-dependent pathway
  • Promotes T cell activation
  • Amplifies IFN-γ-mediated anticancer activity
  • Composed of a PTPN2 ligand, a linker, and a VHL ligand

Catalog No. 50-003-61787


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