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Medchemexpress LLC PVD-06 | 3032975-48-4 | 98.3% | 1074.13 | 25 MG
Supplier: Medchemexpress LLC 25MGHY149760
PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM (selectivity index >60-fold over PTP1B). It induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-γ-mediated anticancer activity. It can be used to further investigate PTPN2 in diseases such as leukemia and melanoma.
- Induces PTPN2 degradation
- Reduces PTPN2 protein levels
- Enhances phosphorylation of STAT1 in Jurkat cells
- Promotes T cell proliferation under CD3/CD28 stimulation
- Amplifies B16F10 cell growth inhibition in the presence of IFN-γ
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