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AdipoGen PX-12 (1 mg)
Supplier: AdipoGen AGCR13739M001
Chemical. CAS: 141400-58-0. Formula: C7H12N2S2. MW: 188.3. PX-12 is a competitive, irreversible inhibitor of thioredoxin 1 (Trx1), acting by binding to Cys73 of this enzyme. PX-12 stimulates apoptosis, down-regulates HIF-1alpha, vascular endothelial growth factor (VEGF) and iNOS, and consequently inhibits proliferation and tumor growth in animal models. It has also been reported to inhibit tubulin polymerization in vitro, induce cell cycle arrest at G2/M phase and inhibit growth, migration and invasion of several cancer cell lines. PX-12 shows antiviral activity against HIV-1, by inhibiting the enzymatic activity of Trx1 and the Trx1-dependent disulfide reduction of gp120. Microtubule polymerization and formation of acetylated microtubules are inhibited as well, activities shown to be required for HIV-1 life cycle propagation. PX-12 potentially inhibits the Mpro/3C-like protease of SARS-CoV-2, consequently inhibiting viral transcription and replication.
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