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Apexbio Technology LLC PX-478 2HCl 685898-44-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B60045.1
PX-478 2HCl (CAS 685898-44-6) commonly known as PX-478 is a small molecule inhibitor targeting hypoxia-inducible factor-1 (HIF-1 ) a transcription factor involved in regulating cellular responses to hypoxic stress including glycolysis angiogenesis and erythropoiesis PX-478 reduces HIF-1 protein levels in multiple tumor cell lines under both normoxic and hypoxic conditions demonstrating IC50 values around 20-30 M depending on cell type In xenograft studies with C6 tumor-bearing mice oral administration of PX-478 inhibited HIF-1 transcriptional activity within tumor hypoxic zones PX-478 is utilized as a research tool to examine hypoxia-related tumor biology and to explore therapeutic sensitization strategies
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