Invitrogen™ PXR (SXR) Ligand Binding Domain Protein, GST Tag Recombinant Protein

Catalog No.	Quantity
PV4841	50 μg

Catalog No. PV4841 Supplier Invitrogen™ Supplier No. PV4841

Description

Recombinant Protein

Pregnane X Receptor (Steroid and Xenobiotic Receptor), Ligand Binding Domain (PXR (SXR)-LBD) is a 64.7 kDa recombinant human protein (amino acids 111-434) expressed as a GST fusion protein in baculovirus-infected insect cells. PXR (SXR)-LBD was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator recruitment or displacement studies. Protein Form: Recombinant, Ligand Binding Domain.

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Specifications

• Accession Number: O75469
• Concentration: See Label
• For Use With (Application): Binding Assay
• Formulation: Proprietary buffer with no preservative
• Gene ID (Entrez): 8856
• Name: PXR (SXR) Ligand Binding Domain Protein, GST Tag
• Purification Method: Purified
• Quantity: 50 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: BXR; mPXR; Nr1i2; Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; nuclear receptor subfamily 1, group I, member 2; ONR 1; ONR1; orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR; PAR 1; PAR 2; PAR q; PAR1; PAR2; PARq; pregnane X nuclear receptor variant 2; Pregnane X receptor; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); PRR; PXR; PXR.1; PXR.2; PXR1; SAR; Steroid and xenobiotic receptor; SXR
• Common Name: PXR
• Gene Symbol: NR1I2
• Protein Length: 111-434
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: 111-434
• Content And Storage: Store in ultra-cold freezer (-68 to -85°C).
• Shipping Condition: Dry Ice
• Expression System: Baculovirus
• Protein Family: Receptors
• Protein Form: Recombinant, Ligand Binding Domain
• Form: Liquid
• Protein Subtype: Hormone Receptors
• Research Category: Drug Discovery: Neurobiology