Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC PXS-5120A | 2125955-70-4 | 98.1% | 100 MG
Supplier: Medchemexpress LLC HY130242100MG
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. It exhibits high selectivity for LOXL2 over LOXL and effectively inhibits various forms of LOXL2 and LOXL3. In vivo studies demonstrate its rapid absorption and hydrolysis to the active free base, maintaining therapeutic plasma concentrations for extended periods.
- Potent, irreversible fluoroallylamine inhibitor of LOXL2/3
- Exhibits anti-fibrotic activity
- Over 300-fold selective for LOXL2 over LOXL
- Effectively inhibits recombinant human LOXL2, human fibroblast LOXL2, recombinant mouse LOXL2, recombinant rat LOXL2, and collagen oxidation assay
- Inhibits recombinant human LOXL3 and recombinant human LOXL4
- Readily absorbed orally and rapidly hydrolyzed to the active free base
- Maintains plasma concentrations above LOXL2 IC50 for prolonged periods in mice
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?