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Medchemexpress LLC PXS-5153A monohydrochloride | 2125956-82-1 | 99.59% | 438.95 | 100 MG
Supplier: Medchemexpress LLC HY114286A100MG
PXS-5153A monohydrochloride is a potent, selective, orally active, and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor. It has an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. This compound can reduce crosslinks and ameliorate fibrosis.
- Potent, selective, orally active, and fast-acting LOXL2/LOXL3 inhibitor.
- IC50 of <40 nM for LOXL2 across all mammalian species.
- IC50 of 63 nM for human LOXL3.
- >40-fold selective for LOXL2 over LOX and LOXL1.
- >700-fold selective over other related amine oxidases.
- Fast-acting, with enzymatic activity almost entirely blocked within 15 minutes.
- Reduces crosslinks and ameliorates fibrosis.
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