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Medchemexpress LLC PXS-5153A (monohydrochloride) | 2125956-82-1 | 99.6% | 438.95 | 50 MG
Supplier: Medchemexpress LLC HY114286A50MG
PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorate fibrosis.
- Exhibits an IC50 of <40 nM for LOXL2 across all mammalian species tested.
- Also inhibits human LOXL3 with an IC50 value of 63 nM.
- Is >40-fold selective for LOXL2 over both LOX and LOXL1 and >700-fold selective over other related amine oxidases.
- Is a fast acting inhibitor, with enzymatic activity almost entirely blocked within 15 minutes.
- Reduces crosslinks and ameliorates fibrosis.
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