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Medchemexpress LLC PXS-5505 anhydrous (LOX-IN-3 dihydrochloride) | 2409964-23-2 | 99.9% | 353.24 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY138625A50MG

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PXS-5505 anhydrous, also known as LOX-IN-3 dihydrochloride, is an orally active inhibitor of lysyl oxidase (LOX). This compound has potential applications in research related to fibrosis, cancer, and angiogenesis.

  • Orally active lysyl oxidase inhibitor.
  • Can be used for fibrosis research.
  • Can be used for cancer research.
  • Can be used for angiogenesis research.
  • Inhibits human LOXL2 activity with an IC50 value of <1 μM.
  • Inhibits bovine LOX activity with an IC50 value of <10 μM.
  • Exhibits sustained inhibition of LOXL1 and LOXL2.
  • Less active against SSAO/VAP-1 and MAO-B activities.
  • Completely abolished lysyl oxidase activity in rats at 30 mg/kg orally.
  • Reduces kidney fibrosis in unilateral ureteric obstruction (UUO) mice model at 10 mg/kg orally.
  • Reduces lung fibrosis in mice at 15 mg/kg orally in a bleomycin-induced model.

Catalog No. 50-003-51469


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