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Medchemexpress LLC Pyrazine | 290-37-9 | 99.97% | 80.09 | 500 G
Supplier: Medchemexpress LLC HYW013040500G
Pyrazine is an aromatic nitrogen-containing heterocyclic compound with two nitrogen atoms, known for its electron-deficient property. It serves as a key pharmacophore in various drugs and acts as the core skeleton of derivatives with anticancer, antimycobacterial, antithrombotic, and anti-inflammatory activities.
- Undergoes Chichibabin reaction with sodamide to form 2-aminopyrazine.
- Reacts with 30% H2O2/CH3COOH at 70-80 °C to form mono and dioxide products.
- Can be synthesized via catalytic dehydrogenation of ethanolamine or via double condensation of a 1,2-dicarbonyl compound with equimolar 1,2-diamine followed by oxidation.
- It is a monobasic compound with a pKa of 0.65, protonated at N-1, and only undergoes N,N-diprotonation in very strong acidic media.
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