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Medchemexpress LLC Pyridostatin hydrochloride | 1781882-65-2 | C31H37Cl5N8O5 | 5 MG
Supplier: Medchemexpress LLC HY15176A5MG
Pyridostatin hydrochloride is a G-quadruplex DNA stabilizing agent that targets DNA and RNA G4s in cells. It promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. This selective G-quadruplex DNA-binding small molecule also targets the proto-oncogene Src, reducing SRC protein levels and cellular motility in human breast cancer cells.
- G-quadruplex DNA stabilizing agent (Kd=490 nM)
- Targets DNA and RNA G4s in cells
- Promotes growth arrest in human cancer cells
- Induces replication- and transcription-dependent DNA damage
- Targets proto-oncogene Src
- Reduces SRC protein levels and cellular motility
- Causes neurite retraction, synaptic loss, and neuronal death
- Induces formation of DNA DSBs
- Downregulates BRCA1 protein at transcriptional level
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